The Cool Science of Hot Peppers

any chili peppers look as fiery as they taste! A single chili pepper can be enough to spice up an entire family’s meal.
“A quarter of the world’s population eats chilies every day,” notes Joshua Tewksbury. He is a biologist who spent 10 years studying wild chili peppers. He also happens to enjoy eating hot, spicy food.
Chili peppers do much more than burn people’s mouths. Scientists have discovered many uses for the chemical that gives these veggies their zing. Calledcapsaicin (Kap-SAY-ih-sin), it’s the main ingredient in pepper spray. Some people use this weapon for self-defense. The spray’s high levels of capsaicin will burn the eyes and throats of attackers — but won’t kill people. In smaller doses, capsaicin can relieve pain, help with weight loss and possibly affect microbes in the gut to keep people healthier. Now how cool is that?

A taste for spice

Why would anyone willingly eat something that causes pain? Capsaicin triggers a rush of stress hormones. These will make the skin redden and sweat. It can also make someone feel jittery or energized. Some people enjoy this feeling. But there is another reason why chilies show up on dinner plates the world over. Hot peppers actually make food safer to eat.
When food sits out in warm weather, microbes on the food start to multiply. If people eat food with too many of these germs, they risk getting very sick. The cold temperature inside a refrigerator stops most microbes from growing. That’s why most people today rely on refrigerators to keep their food fresh. But long ago, those appliances weren’t available. Chilies were. Their capsaicin and other chemicals, it turns out, can slow or stop microbial growth. (Garlic, onion and many other cooking spices can, too.)
Before refrigerators, people living in most hot parts of the world developed a taste for spicy foods. Examples include hot Indian curries and fiery Mexican tamales. This preference emerged over time. The people who first added hot peppers to their recipes probably had no idea chilies could make their food safer; they just liked the stuff. But people who ate the spicy food tended to get sick less often. In time, these people would be more likely to raise healthy families. This led to populations of hot-spice lovers. People who came from cold parts of the world tended to stick with blander recipes. They didn’t need those spices to keep their food safe.

Why chilies hurt

The heat of a chili pepper is not actually a taste. That burning feeling comes from the body’s pain response system. Capsaicin inside the pepper activates a protein in people’s cells called TRPV1. This protein’s job is to sense heat. When it does, it alerts the brain. The brain then responds by sending a jolt of pain back to the affected part of the body.
Normally, the body’s pain response helps prevent serious injury. If a person accidentally places fingers on a hot stove, the pain makes him or her yank that hand back quickly. The result: a minor burn, not permanent skin damage.
Biting into a jalapeño pepper has the same effect on the brain as touching a hot stove. “[Peppers] trick our brain into thinking we are being burned,” says Tewksbury, who now leads the Boulder, Colo., office of Future Earth. (The group promotes research to protect Earth’s resources). Pepper plants likely evolved their fake-out technique to keep certain animals from eating up their fruit, according to Tewksbury’s research.
People, mice and other mammals feel the burn when they eat peppers. Birds do not. Why would peppers develop a way to keep mammals away but attract birds? It ensures the plants’ survival. Mammals have teeth that smash seeds, destroying them. Birds swallow pepper seeds whole. Later, when birds poop, the intact seeds land in a new place. That lets the plant spread.
People managed to outsmart the pepper when they realized that a chili’s pain doesn’t cause any lasting damage. Those with pepper allergies or stomach conditions do need to stay away from chilies. But most people can safely eat hot peppers.

Pain fights pain

Capsaicin does not actually damage the body in the same way that a hot stovetop will — at least not in small amounts. In fact, the chemical can be used as a medicine to help relieve pain. It may seem bizarre that what causes pain might also make pain go away. Yet it’s true.
Tibor Rohacs is a medical researcher at New Jersey Medical School in Newark. He recently studied how capsaicin works to deaden pain. Researchers already knew that when capsaicin turns on the TRPV1 protein, it’s like turning on a bright light. Whenever the light is on, the person experiences pain. Rohacs and his colleagues then uncovered a chemical chain reaction that later silences this pain. Essentially, he says, the light “shines so brightly that after a while, the bulb burns out.” Then the TRPV1 protein can’t turn back on again. When this happens, the brain no longer finds out about painful sensations. The team published its findings in the journal Science Signaling in February 2015.
The human body is good at repairing itself, however. Eventually, the pain will fix this pain system and can once again send pain alerts to the brain. However, if the TRPV1 protein is activated often, the pain system may not get a chance to repair itself in time. The person will only feel discomfort or burning at first. Then he or she will experience relief from other types of pain.
For example, people with arthritis (Arth-RY-tis) regularly have pain in their fingers, knees, hips or other joints. Rubbing a cream containing capsaicin onto the painful area may burn or sting at first. After a while, however, the area will become numb.
Rohacs warns that capsaicin creams don’t seem to soak deeply enough into the skin to totally eliminate pain. He says other researchers are currently testing capsaicin patches or injections. These would likely do a better job at halting pain. Unfortunately, these therapies tend to hurt a lot more than a cream — at least in the beginning. Someone who can tough out the initial discomfort, however, could get relief that lasts for weeks, not hours.

Sweat it out

Chili peppers also may help people lose weight. However, a person can’t simply eat hot, spicy food and expect to shed pounds. “It’s not a magic remedy,” warns Baskaran Thyagarajan. He works at the University of Wyoming in Laramie. As a pharmacologist, he studies the effects of medicines. His team is now working to create a drug to make the body burn through fat more quickly than usual. A primary ingredient: capsaicin.
In the body, capsaicin triggers a stress reaction known as the fight-or-flight response. It normally occurs when someone (or some animal) senses a threat or danger. The body responds by preparing to either run away or stand and fight. In people, the heart’s beating will speed up, breathing will quicken and the blood will send a boost of energy to the muscles.
To fuel the fight-or-flight response, the body burns through stores of fat. Just as a bonfire chews through wood to produce hot flames, the human body turns fat from food into the energy it needs. Thyagarajan’s team is now working on a capsaicin-based drug aimed at helping obese people — those who have more stored fat than their bodies need — to shed their excess weight.
In a 2015 study, his group showed that mice that ate a high-fat diet containing capsaicin did not gain extra weight. But a group of mice that ate only the high-fat diet became obese. Thyagarajan’s group hopes to start testing its new medication on people soon.
Other researchers have already tried similar therapies. Zhaoping Li is a doctor and nutrition specialist at the University of California in Los Angeles. In 2010, Li and her colleagues gave a pill containing a capsaicin-like chemical to obese volunteers. The chemical was called dihydrocapsiate (Di-HY-drow-KAP-see-ayt). It did help the people lose weight. But the change was slow. In the end, it also was too small to make much of a difference, Li believes. She suspects that using capsaicin would have had a bigger effect. Still, she argues, it would never work as a weight loss remedy. Why not? “When we convert the dose that worked on mice or rats to humans, [people] don’t tolerate it.” It’s too spicy! Even in pill form, she points out, capsaicin gives many people upset stomachs.
But Thyagarajan says his team has come up with a spice-proof way to get capsaicin into the body. A doctor would inject the drug directly into areas with a lot of fatty tissue. Magnets would coat each particle. The doctor would use a magnetic belt or wand to hold the particles in place. This should keep the capsaicin from circulating through the body. Thyagarajan believes that this would help prevent side effects.

Spice it up

Capsaicin may be the most exciting chemical inside a chili pepper, but it isn’t the only reason to spice up your diet. Both hot and sweet peppers also have important vitamins and minerals that the body needs. Li’s team is now studying how chilies and other cooking spices change the bacteria living in the human gut. Outside the body, spices help keep dangerous germs from growing on food. Li suspects that inside the body, they may rout bad germs. They might also help good bacteria thrive. She is investigating both ideas now.
A 2015 study even showed that people with spicy diets tend to live longer. Researchers at the Chinese Academy of Medical Sciences in Beijing tracked half a million adults in China for seven years. Those who ate spicy food six or seven days a week were 14 percent less likely to die during those seven years than were people who ate spices less than once a week. And people who regularly ate fresh chilies, in particular, were less likely to die of cancer or heart disease. This result doesn’t necessarily mean that eating hot chilies prevents disease. It may be that people with healthy overall lifestyles tend to prefer spicier foods.
As scientists continue to uncover the secret powers of chili peppers, people will keep spicing up their soups, stews, stir-fries and other favorite dishes. Next time you see a jalapeño on a plate, take a deep breath, then take a bite.

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